Preparations vary greatly in chemical content and quality, and may be standardized regarding quantity of hyperforin (commonly 3% to 5%) or hypericin (commonly 0.3%) constituents. Well-known throughout both the naturopathic and medical communities, St. John’s Wort possesses a laundry list of benefits with a surprisingly safe herbal makeup. Avoid combination.Nimodipine April 2015, Nintedanib: Combined inducers of CYP3A4 and P-gp may decrease the serum concentration of nintedanib. Avoid combination.Jalloh 2017, Stribild August 2012, Irinotecan products: St. John's wort may diminish the therapeutic effect of irinotecan. Consider therapy modification.Bergeron 2005, Bernard 2003, Clark 2006, DeBellis 2005, Go 2010, Hachem 2003, Hendershot 2001, Jones 2004, Lavery 2001, Lawrence 2006, Lorenz 2008, Mason 2008, McClean 2011, Miller 2011, Morales 2005, Packer 2007, Sola 2006, Steinberg 2007, Strouse 2006, Tahir 2004, Taylor 2006, Thomas 2004, Wigen 2002, Zyvox June 2015, Lumefantrine: St. John's wort may decrease the serum concentration of lumefantrine. Consider therapy modification.Adriamycin July 2012, Bartlett 1994, Callies 2003, Christen 1993, Doxorubicin October 2013, Erlichman 1993, Hor 2008, McCaffrey 2013, Rushing 1994, Sandanaraj 2008, Sandler 2004, Sella 1994, Sonneveld 2001, Tidefelt 1994, Toffoli 2004, Vaccher 2001, Dronedarone: St. John's wort may decrease the serum concentration of dronedarone. Buy St John's Wort online and view local Walgreens inventory. Consider therapy modification.Chrubasik-Hausmann 2018, Cabozantinib: St. John's wort may decrease the serum concentration of cabozantinib. Avoid combination.Ella June 2014 Fibristal June 2013], Valbenazine: St. John's wort may decrease the serum concentration of valbenazine. Hypericum perforatum, commonly known as St John's wort, has been used for centuries to treat nerve damage, sciatica and back pain. Antioxidants and interleukins in St. John’s Wort decrease inflammation, making it a practical option for those suffering with aches and pains as well as skin conditions that cause inflammation. Specifically, the risk of serotonin syndrome or serotonin toxicity may be increased. Likewise, monoamine-oxides help the brain retain even more of these feel-good chemicals. The side effects of St John's Wort will be different for each person, and will depend on many factors such as frequency of use, pre-existing medical conditions and personal sensitivity to the plant, to name a few. Shingles. Monitor therapy.Arold 2005, Johne 1999, Mueller 2004, Docetaxel: St. John's wort may increase clearance and decrease AUC. St. John’s Wort For Urinary Incontinence Widely used in the treatment of depression, St John’s Wort eases contractions of the bladder and, therefore, helps with incontinence. Consider therapy modification.Rexulti July 2015, Brigatinib: St. John's wort may decrease the serum concentration of brigatinib.Alunbrig April 2017, Bupropion: St. John's wort may decrease the serum concentration of bupropion. Monitor therapy.Altman 2010, Boyer 2005, Gener 2010, George 2011, Gollapudy 2012, Sorscher 2002, Stanford 1999, Stanford 2010, Turkel 2001, Antihepaciviral combination products: CYP3A4 inducers (moderate) may decrease the serum concentration of antihepaciviral combination products. Avoid combination.Martin 2011, Vandetanib April 2011, Velpatasvir: CYP3A4 inducers (moderate) may decrease the serum concentration of velpatasvir. Avoid combination.Biktarvy February 2018, Boceprevir: St. John's wort may decrease the serum concentration and AUC of boceprevir. Consider therapy modification.Azilect May 2014, Dingemanse 1996, Duval 2013, Emsam March 2015, Fernandes 2011, Garcia-Monco 1995, Gitlin 1997, Hilli 2009, Hinds 2000, Jermain 1992, Laine 1997, Lefebvre 1995, Montastruc 1993, Panisset 2015, Richard 1997, Ritter 1997, Smith 2015, Suchowsersky 1990, Toyama 1994, Waters 1994, Wu 2009, Xadago March 2017, Zelapar July 2014, Zomberg 1991, Antipsychotic agents: Serotonin modulators may enhance the adverse/toxic effect of antipsychotic agents. When taken as a capsule for prolonged use, St. John’s Wort is typically used 3 times per day. St. John's wort may decrease serum concentrations of the active metabolite(s) of irinotecan products. Additionally, bioactivities of some compounds were dependent on light, whereas others were light independent. Consider therapy modification.Russo 2014, Sugimoto 2001, Ibrutinib: St. John's wort may decrease the serum concentration of ibrutinib. Monitor therapy.Drucker 2011, Lankerani 2004, Naldi 1999, Photofrin June 2011, Progestins (contraceptive): St. John's wort may decrease the therapeutic effect of progestins (contraceptive). The naphthodianthrones (hypericin, pseudohypericin) and the phloroglucinols (hyperforin, adhyperforin) are the most characterized.Russo 2014, Naphthodianthrons occur in St. John's wort in concentrations of less than 0.1% to 0.15%. Consider therapy modification.Biaxin May 2011, Hafner 1998, Kakuda 2014, CloZAPine: St John's wort may decrease the serum concentration of clozapine. A Cochrane review of antidepressants for smoking cessation also examined evidence for herbal products, including St. John's wort. Monitor therapy.Bosak 2014, Martini 2015, Skelaxin March 2018, Surmaitis 2015, Metformin: St John's wort may decrease the renal clearance of metformin. Organic St John’s Wort Beeswax Dry Skin Cream- Deep Cleansing Herbal Salve Treatment For … St John's Wort (Hypericum Perforatum) Infused Oil Extract (Macerated Oil), 1.7 Oz - 50 Ml/the … Potent inhibition of sperm motility was observed in vitro.Ondrizek 1999. As an antispasmodic, St. John’s wort helps to relax muscles spasms including spasms in the lungs, colon, and reproductive tract. Consider therapy modification.Gilotrif November 2013, Aminolevulinic acid (systemic): Photosensitizing agents may enhance the photosensitizing effect of aminolevulinic acid (systemic). Prenolone Plus Body Cream has the same high-quality, natural ingredients as Prenolone Body Cream with the addition of DHEA (dehydroepiandrosterone ). This flower is also rich in flavonoids which are famous for their antioxidant and anti-inflammatory benefits. Specifically, St John's wort may decrease isavuconazole serum concentrations. St. John’s wort helps in peripheral neuropathy by relieving nerve pain and supporting nerve repair. Consider therapy modification.Russo 2014, Dienogest: St. John's wort may decrease the serum concentration of dienogest. The flower petals have black or yellow glandular dots and lines. Amphetamines: Amphetamines may enhance the adverse/toxic effect of serotonin modulators. St. John's wort is a perennial plant native to Europe but found throughout the United States and parts of Canada. St. John's wort (Hypericum perforatum) is a flowering shrub native to Europe. Zolpidem: St. John's wort may decrease the serum concentration of zolpidem. Monitor therapy.Lilja 2004, Selectol July 2017, Ceritinib: St. John's wort may decrease the serum concentration of ceritinib. Avoid combination.Movantik September 2014, Neratinib: CYP3A4 inducers (moderate) may decrease the serum concentration of neratinib. Monitor therapy.Izzo 2016, Methylene blue: Methylene blue may enhance the serotonergic effect of serotonin modulators. These changes were determined to be clinically insignificant.Jackson 2014, Bortezomib: St. John's wort may decrease the serum concentration of bortezomib. St John's wort may decrease the serum concentration of quetiapine. Monitor therapy.Drucker 2011, Lankerani 2004, Naldi 1999, Visudyne June 2012, Vincristine (liposomal): St. John's wort may decrease the serum concentration of vincristine (liposomal). Impaired glucose tolerance has been documented in healthy volunteers. Consider therapy modification.Russo 2014, Tolvaptan: St. John's wort may decrease the serum concentration of tolvaptan. Monitor therapy.Ovestin September 2015, Estrogen derivatives (contraceptive): St. John's wort may decrease the therapeutic effect of estrogen derivatives (contraceptive). Avoid combination.Bach 2004, Grubb 2012, Hanna 2014, Harvey 2010, Hencken 2016, Heritier Barras 2010, Izdes 2014, Kartha 2006, Khan 2007, Khavandi 2008, Larson 2015, Majithia 2006, Martindale 2003, Martino 2016, Mathew 2006, McDonnell 2012, Methylene blue September 2014, Ng 2008, Nicolaou 2016, Pollack 2009, Provayblue April 2014, Ramsay 2007, Rowley 2009, Schwiebert 2009, Shanmugam 2008, Smith 2015, Stanford 1999, Stanford 2010, Sweet 2007, Top 2014, Methylphenidate: Methylphenidate may enhance the adverse/toxic effect of serotonin modulators. St. John’s Wort influences many hormones, but it’s primarily known to help regulate common female hormones as well as stress hormones. Saint johns wort, when used externally, will provide protection against the sun, as well as relieve sunburns. This could result in serotonin syndrome. Hypericin and pseudohypericin inhibit a variety of encapsulated viruses, including HIV.Upton 1997, 3-Hydroxy lauric acid obtained from H. perforatum exhibited light-independent, anti-HIV activity in an in vitro experiment.Maury 2009, Clinical trials of St. John's wort use in HIV are limited by the prevalence of interactions between St. John's wort and standard HIV therapy. It’s an herbal supplement that doesn’t require a prescription and you can buy it at a health food store. Hyperforin exhibits linear pharmacokinetics at doses up to 600 mg, after which plasma levels tend to be lower than expected. Meadowsweet leaves and flower tops and white willow bark also act as anti-inflammatory agents, which can relieve pain. Avoid combination.Byakika-Kibwika 2012, Coartem April 2013, Huang 2012, Kredo 2011, Lurasidone: St. John's wort may decrease the serum concentration of lurasidone. From its mood-boosting ability to its healing advantage, St. John’s Wort benefits are far too numerous and powerful to be overlooked. The patient was administered 2 regimens given 18 months apart of Hypericum dry extract 300 mg 3 times daily for 8 weeks.Kummer 2016, Meta-analyses, including Cochrane meta-analyses, of quality clinical trials have been conducted to examine effects of St. John's wort in comparison with placebo and antidepressant therapy for treatment of depression.Kasper 2008, Linde 2000, Linde 2005, Linde 2015, Magni 2013, Rahimi 2009 In some studies of mild, moderate, and majorLinde 2000, Seifritz 2016 depression, St. John's wort was more effective than placebo and similarly effective as standard antidepressants.Kasper 2008, Linde 2000, Linde 2005, Linde 2015, Rahimi 2009, Sarris 2007, Seifritz 2016, Thachil 2007 Adverse effects are lower for St. John's wort than for standard antidepressants.Asher 2017, Knüppel 2004, Linde 2000, Qaseem 2016, Rahimi 2009, Thachil 2007 A previous Cochrane review found insufficient evidence to support a place in therapy for St. John's wort in treating major depressionLinde 2005; however, more recent trials and analysis of participants meeting criteria for major depression have led to a somewhat more positive, but cautious, recommendation for Hypericum.Linde 2000, Qaseem 2016 Issues raised in the meta-analyses include the heterogeneity of older clinical trials, the wide variation and quality of Hypericum preparations, use of comparatively low doses of pharmaceutical antidepressants, and the emergence of more favorable trials.Asher 2017, Linde 2000, Linde 2005, Qaseem 2016, Sarris 2007 Limited evidence is available for use in depression in adolescentsCharrois 2007, Sarris 2007, Walter 1999 or the elderly, or for patients with comorbid conditions such as Alzheimer diseaseChatterjee 1999 or anxiety.Sarris 2009 However, one analysis of 4 studies (N=1,058) that used a stabilized dry extract of H. perforatum, WS 5570, showed a significant improvement in depression scores (P<0.01) compared to placebo in younger patients (younger than 60 years) as well as older patients (60 years of age and older).Kasper 2015, More recent meta-analyses examining the benefits and risks of St. John's wort compared to selective serotonin reuptake inhibitors (SSRIs), specifically in patients with major depressive disorder (MDD), found no statistically significant difference in response, remission, and depression scores between the 2 treatments. Today, it’s been successfully cultivated in other countries, including the United States, Russia and China. It’s important to discuss taking St. John’s Wort with your doctor as it can impact the effectiveness of some prescriptions such as antidepressants, birth control pills and cancer medications. Avoid combination.Russo 2014, Esomeprazole: St. John's wort may decrease the serum concentration of esomeprazole. Avoid combination.Ranexa July 2011, Regorafenib: St. John's wort may decrease the serum concentration of regorafenib. Avoid combination.Iclusig December 2012, Porfimer: Photosensitizing agents may enhance the photosensitizing effect of porfimer. Topical St. John's wort preparations such as oils or tinctures are used for the treatment of minor wounds and burns, sunburns, abrasio … St. John’s wort is natural. Avoid combination.Tagrisso August 2016, Oxycodone: St. John's wort may decrease the serum concentration of oxycodone. The St. John’s Wort plant originated in Europe where it grew wild as a woody shrub. Weakest effects were seen for Salmonella typhimurium and 2 strains of Pseudomonas aeruginosa.Bejaoui 2017, Antiviral activity has been reported for influenza, herpes simplex types 1 and 2 (HSV-1, HSV-2), Sindbis virus, poliovirus, retrovirus infection in vitro and in vivo, murine cytomegalovirus, and hepatitis C.Bombardelli 1995, Jacobson 2001, Müller 2004, Newall 1996, Upton 1997 Hypericin and pseudohypericin exert unique effective antiviral actions, possibly because of nonspecific associations with cellular and viral membranes. There are approximately 370 species in the genus Hypericum, which is derived from the Greek words "hyper" and "eikon" meaning "over an apparition," alluding to the plant's ancient use to ward off evil spirits.
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